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  1. Sirtuin 1 (SIRT1), is a nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase and a candidate gene for depression. Nicotinamide (NAM), a form of vitamin B3, is reported as a potential inhibitor o...

    Authors: Zhuxi Liu, Caiqin Li, Xuelian Fan, Yifang Kuang, Xu Zhang, Lei Chen, Jinjing Song, Ying Zhou, Eiki Takahashi, Guang He and Weidong Li

    Citation: Molecular Brain 2020 13:162

    Content type: Short report

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  2. Previous studies have shown that CCL2 may cause chronic pain, but the exact mechanism of central sensitization is unclear. In this article, we further explore the presynaptic role of CCL2. Behavioral experimen...

    Authors: Sui-Bin Ma, Hang Xian, Wen-Bin Wu, Shuo-Yao Ma, Yu-Ke Liu, Yu-Tong Liang, Huan Guo, Jun-Jun Kang, Ying-Ying Liu, Hui Zhang, Sheng-Xi Wu, Ceng Luo and Rou-Gang Xie

    Citation: Molecular Brain 2020 13:161

    Content type: Research

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  3. CHD8 encodes a chromatin-remodeling factor and is one of the most recurrently mutated genes in individuals with autism spectrum disorder (ASD). Although we have recently shown that mice heterozygous for Chd8 muta...

    Authors: Atsuki Kawamura, Yoshifumi Abe, Fumiko Seki, Yuta Katayama, Masaaki Nishiyama, Norio Takata, Kenji F. Tanaka, Hideyuki Okano and Keiichi I. Nakayama

    Citation: Molecular Brain 2020 13:160

    Content type: Research

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  4. Paranodal axoglial junctions are essential for rapid nerve conduction and the organization of axonal domains in myelinated axons. Neurofascin155 (Nfasc155) is a glial cell adhesion molecule that is also requir...

    Authors: Kazuo Kunisawa, Nobuhiko Hatanaka, Takeshi Shimizu, Kenta Kobayashi, Yasuyuki Osanai, Akihiro Mouri, Qian Shi, Manzoor A. Bhat, Atsushi Nambu and Kazuhiro Ikenaka

    Citation: Molecular Brain 2020 13:159

    Content type: Short report

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  5. We investigated whether enhanced interoceptive bodily states of fear would facilitate recognition of the fearful faces. Participants performed an emotional judgment task after a bodily imagery task inside a fu...

    Authors: Won-Mo Jung, Ye-Seul Lee, In-Seon Lee, Christian Wallraven, Yeonhee Ryu and Younbyoung Chae

    Citation: Molecular Brain 2020 13:157

    Content type: Research

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  6. Long-term memory formation is supported by functional and structural changes of neuronal networks, which rely on de novo gene transcription and protein synthesis. The modulation of the neuronal transcriptome i...

    Authors: David V. C. Brito, Kubra Gulmez Karaca, Janina Kupke, Lukas Frank and Ana M. M. Oliveira

    Citation: Molecular Brain 2020 13:156

    Content type: Research

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  7. Olig2 transcription factor is essential for the maintenance of neural progenitor cells (NPCs) in the pMN domain and their sequential specification into motor neurons (MNs) and oligodendrocyte precursor cells (OPC...

    Authors: Min Jiang, Dan Yu, Binghua Xie, Hao Huang, Wenwen Lu, Mengsheng Qiu and Zhong-Min Dai

    Citation: Molecular Brain 2020 13:155

    Content type: Micro report

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  8. Long interspersed element-1 (LINE-1/L1) is the only autonomous transposable element in the human genome that currently mobilises in both germline and somatic tissues. Recent studies have identified correlation...

    Authors: Abigail L. Savage, Ana Illera Lopez, Alfredo Iacoangeli, Vivien J. Bubb, Bradley Smith, Claire Troakes, Nada Alahmady, Sulev Koks, Gerald G. Schumann, Ammar Al-Chalabi and John P. Quinn

    Citation: Molecular Brain 2020 13:154

    Content type: Research

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  9. Excitatory amino acid carrier 1 (EAAC1) is an important subtype of excitatory amino acid transporters (EAATs) and is the route for neuronal cysteine uptake. CoCl2 is not only a hypoxia-mimetic reagent but also an...

    Authors: Han-Byeol Kim, Ji-Young Yoo, Seung-Yeon Yoo, Jun-Ho Lee, Wonseok Chang, Hye-Sun Kim, Tai-Kyoung Baik and Ran-Sook Woo

    Citation: Molecular Brain 2020 13:153

    Content type: Research

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  10. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Kohei Koga, Akihiro Yamada, Qian Song, Xu-Hui Li, Qi-Yu Chen, Ren-Hao Liu, Jun Ge, Cheng Zhan, Hidemasa Furue, Min Zhuo and Tao Chen

    Citation: Molecular Brain 2020 13:152

    Content type: Correction

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    The original article was published in Molecular Brain 2020 13:49

  11. Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline with accumulation of amyloid beta (Aβ) and neurofibrillary tangles that usually begins 15–30 years before...

    Authors: Md. Ali Bin Saifullah, Okiru Komine, Yutao Dong, Kazuya Fukumoto, Akira Sobue, Fumito Endo, Takashi Saito, Takaomi C. Saido, Koji Yamanaka and Hiroyuki Mizoguchi

    Citation: Molecular Brain 2020 13:147

    Content type: Research

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  12. The canonical physiological role of leptin is to regulate hunger and satiety acting on specific hypothalamic nuclei. Beyond this key metabolic function; leptin also regulates many aspects of development and fu...

    Authors: Camille Dumon, Yasmine Belaidouni, Diabe Diabira, Suzanne M. Appleyard, Gary A. Wayman and Jean-Luc Gaiarsa

    Citation: Molecular Brain 2020 13:151

    Content type: Short report

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  13. The Sigma-1 receptor (σ1R) has emerged as an interesting pharmacological target because it inhibits analgesia mediated by mu-opioid receptors (MOR), and also facilitates the development of neuropathic pain. Ba...

    Authors: Pilar Sánchez-Blázquez, Elsa Cortés-Montero, María Rodríguez-Muñoz, Manuel Merlos and Javier Garzón-Niño

    Citation: Molecular Brain 2020 13:150

    Content type: Research

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  14. Low-voltage-activated T-type calcium channels are important contributors to nervous system function. Post-translational modification of these channels has emerged as an important mechanism to control channel a...

    Authors: Vendula Ficelova, Ivana A. Souza, Leos Cmarko, Maria A. Gandini, Robin N. Stringer, Gerald W. Zamponi and Norbert Weiss

    Citation: Molecular Brain 2020 13:149

    Content type: Micro report

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  15. Neuronal activity-regulated gene transcription underlies plasticity-dependent changes in the molecular composition and structure of neurons. A large number of genes regulated by different neuronal plasticity i...

    Authors: Johanna Denkena, Andrea Zaisser, Barbara Merz, Bertram Klinger, Dietmar Kuhl, Nils Blüthgen and Guido Hermey

    Citation: Molecular Brain 2020 13:148

    Content type: Research

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  16. Protrudin is a protein that resides in the membrane of the endoplasmic reticulum and is highly expressed in the nervous system. Although mutations in the human protrudin gene (ZFYVE27, also known as SPG33) give r...

    Authors: Michiko Shirane, Hirotaka Shoji, Yutaka Hashimoto, Hiroyuki Katagiri, Shizuka Kobayashi, Toshiya Manabe, Tsuyoshi Miyakawa and Keiichi I. Nakayama

    Citation: Molecular Brain 2020 13:146

    Content type: Research

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  17. Itch is defined as an unpleasant sensation that provokes a desire to scratch. Our understanding of neuronal circuits for itch information transmission and processing in the spinal dorsal horn (SDH) has progres...

    Authors: Keisuke Koga, Yuto Shiraishi, Ryo Yamagata, Hidetoshi Tozaki-Saitoh, Miho Shiratori-Hayashi and Makoto Tsuda

    Citation: Molecular Brain 2020 13:144

    Content type: Research

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  18. Traumatic injury to the spinal cord initiates a series of pathological cellular processes that exacerbate tissue damage at and beyond the original site of injury. This secondary damage includes oxidative stres...

    Authors: Madhuvika Murugan, Jiaying Zheng, Gongxiong Wu, Rochelle Mogilevsky, Xin Zheng, Peiwen Hu, Junfang Wu and Long-Jun Wu

    Citation: Molecular Brain 2020 13:143

    Content type: Research

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  19. To prevent or delay the onset of Alzheimer’s disease (AD), we must understand its molecular basis. The great majority of AD cases arise sporadically with a late onset after 65 years of age (LOAD). However, rar...

    Authors: Karissa Barthelson, Stephen Martin Pederson, Morgan Newman and Michael Lardelli

    Citation: Molecular Brain 2020 13:142

    Content type: Research

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  20. α2-Antiplasmin (α2AP), a principal physiological plasmin inhibitor, is mainly produced by the liver and kidneys, but it is also expressed in several parts of the brain, including the hippocampus and cerebral c...

    Authors: Eri Kawashita, Keiichi Ishihara, Haruko Miyaji, Yu Tanishima, Akiko Kiriyama, Osamu Matsuo and Satoshi Akiba

    Citation: Molecular Brain 2020 13:140

    Content type: Research

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  21. The comorbidities of depression and chronic pain have long been recognized in the clinic, and several preclinical studies have demonstrated depression-like behaviors in animal models of chronic pain. These fin...

    Authors: Ryuto Hara, Daiki Takahashi, Tatsuhiro Takehara, Taiju Amano and Masabumi Minami

    Citation: Molecular Brain 2020 13:139

    Content type: Micro report

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  22. Recombinant adeno-associated viruses (rAAVs), particularly those that permit efficient gene transfer to neurons from axonal terminals or across the blood–brain barrier, are useful vehicles for structural and f...

    Authors: Kunzhang Lin, Xin Zhong, Lei Li, Min Ying, Tian Yang, Zhijian Zhang, Xiaobin He and Fuqiang Xu

    Citation: Molecular Brain 2020 13:138

    Content type: Methodology

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  23. Mutations in the Vacuolar protein sorting 35 (VPS35) gene have been linked to familial Parkinson’s disease (PD), PARK17. VPS35 is a key component of the retromer complex, which plays a central role in endosomal t...

    Authors: Keiko Bono, Chikako Hara-Miyauchi, Shunsuke Sumi, Hisayoshi Oka, Yasuyuki Iguchi and Hirotaka James Okano

    Citation: Molecular Brain 2020 13:137

    Content type: Research

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  24. Cerebral microinfarcts (MIs) lead to progressive cognitive impairments in the elderly, and there is currently no effective preventative strategy due to uncertainty about the underlying pathogenic mechanisms. O...

    Authors: Xiao-fei He, Ge Li, Li-li Li, Ming-yue Li, Feng-yin Liang, Xi Chen and Xi-quan Hu

    Citation: Molecular Brain 2020 13:135

    Content type: Research

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  25. Most individuals undergo traumatic stresses at some points in their life, but only a small proportion develop stress-related disorders such as anxiety diseases and posttraumatic stress disorder (PTSD). Althoug...

    Authors: Min-Jae Jeong, Changhee Lee, Kibong Sung, Jung Hoon Jung, Jung Hyun Pyo and Joung-Hun Kim

    Citation: Molecular Brain 2020 13:134

    Content type: Research

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  26. Alzheimer’s disease (AD) is a highly prevalent neurodegenerative disease characterized by Aβ accumulation and tau hyperphosphorylation. Epidemiological evidence for a negative correlation between cancer and AD...

    Authors: Seong Gak Jeon, Hyun-ju Lee, HyunHee Park, Kyung-Min Han and Hyang-Sook Hoe

    Citation: Molecular Brain 2020 13:131

    Content type: Micro report

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  27. The goal of the present study was to elucidate the mechanism by which long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (lncRNA MALAT1) promotes inflammation in Parkinson’s disease (PD...

    Authors: Li-Jun Cai, Li Tu, Xiao-Mo Huang, Jia Huang, Nan Qiu, Guang-Hong Xie, Jian-Xiong Liao, Wei Du, Ying-Yue Zhang and Jin-Yong Tian

    Citation: Molecular Brain 2020 13:130

    Content type: Research

    Published on:

  28. Chronic pain alters cortical and subcortical plasticity, causing enhanced sensory and affective responses to peripheral nociceptive inputs. Previous studies have shown that ketamine had the potential to inhibi...

    Authors: Isabel D. Friesner, Erik Martinez, Haocheng Zhou, Jonathan Douglas Gould, Anna Li, Zhe Sage Chen, Qiaosheng Zhang and Jing Wang

    Citation: Molecular Brain 2020 13:129

    Content type: Research

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  29. The amygdala plays an important role in the emotional-affective aspects of behaviors and pain, but can also modulate sensory aspect of pain (“nociception”), likely through coupling to descending modulatory sys...

    Authors: Guangchen Ji and Volker Neugebauer

    Citation: Molecular Brain 2020 13:128

    Content type: Short report

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  30. In the central nervous system, hyperpolarization-activated, cyclic nucleotide-gated (HCN1–4) channels have been implicated in neuronal excitability and synaptic transmission. It has been reported that HCN chan...

    Authors: Taku Nakagawa, Toshiharu Yasaka, Noriyuki Nakashima, Mitsue Takeya, Kensuke Oshita, Makoto Tsuda, Ken Yamaura and Makoto Takano

    Citation: Molecular Brain 2020 13:127

    Content type: Research

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  31. Dopamine is involved in many important brain functions, including voluntary motor movement. Dysfunction of the dopaminergic system can induce motor impairments, including Parkinson’s disease. We previously fou...

    Authors: Masayo Fujita, Yukiko Ochiai, Taishi-Clark Takeda, Yoko Hagino, Kazuto Kobayashi and Kazutaka Ikeda

    Citation: Molecular Brain 2020 13:126

    Content type: Micro report

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  32. Frontotemporal dementia (FTD) is amongst the most prevalent early onset dementias and even though it is clinically, pathologically and genetically heterogeneous, a crucial involvement of metabolic perturbation...

    Authors: Blanca I. Aldana, Yu Zhang, Pia Jensen, Abinaya Chandrasekaran, Sofie K. Christensen, Troels T. Nielsen, Jørgen E. Nielsen, Poul Hyttel, Martin R. Larsen, Helle S. Waagepetersen and Kristine K. Freude

    Citation: Molecular Brain 2020 13:125

    Content type: Research

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  33. Glutamate toxicity is a pathomechanism that contributes to neuronal cell death in a wide range of acute and chronic neurodegenerative and neuroinflammatory diseases. Activation of the N-methyl-D-aspartate (NMDA)-...

    Authors: Simon F. Merz, C. Peter Bengtson, Clara Tepohl, Anna M. Hagenston, Hilmar Bading and Carlos Bas-Orth

    Citation: Molecular Brain 2020 13:124

    Content type: Research

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  34. Variants of the cytoplasmic FMR1-interacting protein (CYFIP) gene family, CYFIP1 and CYFIP2, are associated with numerous neurodevelopmental and neuropsychiatric disorders. According to several studies, CYFIP1 re...

    Authors: Gyu Hyun Kim, Yinhua Zhang, Hyae Rim Kang, Seung-Hyun Lee, Jiwon Shin, Chan Hee Lee, Hyojin Kang, Ruiying Ma, Chunmei Jin, Yoonhee Kim, Su Yeon Kim, Seok-Kyu Kwon, Se-Young Choi, Kea Joo Lee and Kihoon Han

    Citation: Molecular Brain 2020 13:123

    Content type: Micro report

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  35. Altered levels of brain-derived neurotrophic factor (BDNF) have been reported in neurologically diseased human brains. Therefore, it is important to understand how the expression of BDNF is controlled under pa...

    Authors: Mamoru Fukuchi, Ryohei Saito, Shojiro Maki, Nami Hagiwara, Yumena Nakajima, Satoru Mitazaki, Hironori Izumi and Hisashi Mori

    Citation: Molecular Brain 2020 13:122

    Content type: Research

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  36. The release of dopamine (DA) into target brain areas is considered an essential event for the modulation of many physiological effects. While the anterior cingulate cortex (ACC) has been implicated in pain rel...

    Authors: Soroush Darvish-Ghane, Clémentine Quintana, Jean-Martin Beaulieu and Loren J. Martin

    Citation: Molecular Brain 2020 13:121

    Content type: Research

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  37. The transplantation of neural progenitor cells (NPCs) derived from human induced pluripotent stem cells (iPSCs) has beneficial effects on spinal cord injury (SCI). However, while there are many subtypes of NPC...

    Authors: Keita Kajikawa, Kent Imaizumi, Munehisa Shinozaki, Shinsuke Shibata, Tomoko Shindo, Takahiro Kitagawa, Reo Shibata, Yasuhiro Kamata, Kota Kojima, Narihito Nagoshi, Morio Matsumoto, Masaya Nakamura and Hideyuki Okano

    Citation: Molecular Brain 2020 13:120

    Content type: Research

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  38. Cav3.2 T-type calcium channels are important mediators of nociceptive signaling, but their roles in the transmission of itch remains poorly understood. Here we report a key involvement of these channels as key...

    Authors: Vinicius M. Gadotti, Joanna M. Kreitinger, Nicholas B. Wageling, Dylan Budke, Philippe Diaz and Gerald W. Zamponi

    Citation: Molecular Brain 2020 13:119

    Content type: Research

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  39. Repressor element 1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) is a transcription repressor and its expression is regulated by the Wnt pathway through β-catenin. Metabotropic...

    Authors: Jéssica M. de Souza, Khaled S. Abd-Elrahman, Fabiola M. Ribeiro and Stephen S. G. Ferguson

    Citation: Molecular Brain 2020 13:118

    Content type: Research

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  40. Serotonin (5-HT) is a well-known modulator of behavioral, physiological, and emotional functions of the forebrain region. We recently discovered alterations of serotonergic synaptic modulations in both, the pr...

    Authors: Fumihito Saitow, Toru Takumi and Hidenori Suzuki

    Citation: Molecular Brain 2020 13:115

    Content type: Short report

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  41. MicroRNAs perform important roles in the post-transcriptional regulation of gene expression. Sequencing as well as functional studies using antisense oligonucleotides indicate important roles for microRNAs dur...

    Authors: Luiz F. Almeida Silva, Cristina R. Reschke, Ngoc T. Nguyen, Elena Langa, Amaya Sanz-Rodriguez, Rogerio R. Gerbatin, Fernanda R. Temp, Mayara L. de Freitas, Ronan M. Conroy, Gary P. Brennan, Tobias Engel and David C. Henshall

    Citation: Molecular Brain 2020 13:114

    Content type: Research

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  42. As the main organelles for the clearance of damaged proteins and damaged organelles, the function of lysosomes is crucial for maintaining the intracellular homeostasis of long-lived neurons. A stable acidic en...

    Authors: Mengling Zhang, Haifeng Lu, Xueshun Xie, Haitao Shen, Xiang Li, Yunhai Zhang, Jiang Wu, Jianqiang Ni, Haiying Li and Gang Chen

    Citation: Molecular Brain 2020 13:113

    Content type: Research

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