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Fig. 5 | Molecular Brain

Fig. 5

From: mGluR5 regulates REST/NRSF signaling through N-cadherin/β-catenin complex in Huntington’s disease

Fig. 5

Chronic CTEP treatment modulates REST/NRSF signaling by N-cadherin/β-catenin complex in zQ175 mice. Representative western blots (a) and quantification of fold change in Src phosphorylation at Y416 (pY416) (b), N-cadherin phosphorylation at Y860 (pY860) (c), β-catenin protein expression (d), REST/NRSF protein expression (e) and SNAP-25 protein expression (f) with the corresponding loading controls in brain lysates from heterozygous zQ175 and wild-type (WT) mice after chronic treatment with either vehicle or CTEP (2 mg/kg) for 12 weeks. N-cadherin-pY860 was normalized to total N-cadherin, and Src-pY416, β-catenin, REST/NRSF and SNAP-25 were normalized to vinculin (n = 5–6 to each group). Values represent mean ± SEM and are expressed as a fraction of the vehicle-treated WT value. * denotes P < 0.05 and statistical significance was assessed by two-way ANOVA and Fisher’s LSD multiple comparisons

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