Fig. 6
From: mGluR5 regulates REST/NRSF signaling through N-cadherin/β-catenin complex in Huntington’s disease
Genetic ablation of mGluR5 modulate REST/NRSF and SNAP-25 mRNA levels in BACHD mice. mRNA levels of REST/NRSF (a and b) and SNAP-25 (c and d) in hippocampus samples from wild-type (WT), mGluR5−/−, BACHD and BACHD/ mGluR5−/− mice at 6 and 12 months of age. mRNA levels were assessed by quantitative RT-PCR, which was performed in triplicate and normalizes to actin mRNA levels (n = 6 to each group). Values represent mean ± SEM and are expressed as a fraction of WT. * denotes P < 0.05 and statistical significance was assessed by one-way ANOVA and Fisher’s LSD multiple comparisons