Fig. 2

Classification of stressed mice through indices of fear generalization and extinction resistance. a K-means clustering analysis of freezing responses that stressed mice (n = 79) display one day after extinction training. Red, high, 38 mice; blue, low, 41 mice (left). K-means clustering analysis of generalization indices of stressed mice (n = 79). Red, high, 39 mice; blue, low, 40 mice (right). b Distribution of mice clustered and denoted as “both high” from fear recall and generalization indices (n = 23 mice [29.11%]), “both low” from both (n = 25 mice [31.65%]), and “mixed” for opposite results from two indices (n = 31 mice [39.24%]). c K-means clustering analysis using fear recall and generalization indices show distinct distributions of susceptible mice (red, both high), resilient mice (blue, both low), and nonallocated mice (black, mixed). d Distributions of fear recall and generalization indices for susceptible, resilient, and unstressed control mice (means ± SEMs)