Fig. 5

Comparison of Mn²⁺ enhancement in the ROIs after noxious stimulation. The IC regions were analyzed by rostral-caudal analysis (a, b). S1HL regions showed increased signals in all groups. However, Torin1-, or XL388-treated rats showed reduced signal intensities (c). Torin1- and XL388-treated rats showed significantly reduced signal intensities at the rostral M1/2 area (d, e). In the comparison of ACC, Torin1- and XL388-treated groups showed a significant reduction in signal enhancement (f). However, V1/2 signals did not show any difference within groups (g). Each group is presented by different colors (control: blue, Torin1: red, and XL388: white). *P < 0.05; **P < 0.01. Data are presented as a mean ± SEM