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Table 1 Summary of significant differences in behavioral tests in App-KI mice in this study vs. previous studies

From: Touchscreen-based location discrimination and paired associate learning tasks detect cognitive impairment at an early stage in an App knock-in mouse model of Alzheimer’s disease

Behavioral tests

Test significance

Significant difference

References

Y-maze

Short-term memory

Yes (6 months)

Saito et al. [13]

Place preference and reversal task

Spatial learning and reversal learning

Yes (13–14 months)

Masuda et al. [16]

Serial reaction time task

Impulsivity and attention

Yes (13–14 months)

 

Place avoidance

Extinction learning

Yes (8–9 months)

 

Delay discounting task

Compulsive behavior

Yes (8–9 months)

 

Novel object recognition

Recognition memory

Not detected (6 months)

Whyte et al. [17]

Y-maze

Working memory

Not detected (6 months)

 

Morris water maze

Spatial reference memory

Not detected (6 months)

 

Open field

Anxiety

Yes (6 months)

 

Fear conditioning

Fear learning

Not detected (15–18 months)

Sakakibara et al. [14]

Elevated plus maze

Anxiety-related behavior

Yes (6–18 months)

 

Barnes maze

Spatial memory

Yes (8 months)

 

Spatial reversal learning

Flexibility and impulse control

Not detected (8 months)

 

Morris water maze

Spatial reference memory

Not detected (10–11 months)

Latif-Hernandez et al. [15]

Cage activity and exploration

Spontaneous activity

Yes (3 and 10 months)

 

Social Preference Social Novelty (SPSN) test

Social memory

Not detected (3, 6, and 10 months)

 

Location discrimination

Pattern separation

Yes (4–5 months)

Present study

Different object–location paired-associate learning

Paired-associative memory

Yes (4–6 months)

 

Visual discrimination, Reversal learning

Cognitive flexibility

Not detected (4–5 months)

 

Morris water maze

Spatial reference memory

Not detected (6 months)