Fig. 3

Anxiety-related behavior of protrudin-deficient mice. a–d Distance traveled (a), vertical activity (b), center time (c), and stereotypic counts (d) for the open-field test. e–h Distance traveled in the light and dark chambers (e), time spent in the light chamber (f), number of transitions between the light and dark chambers (g), and latency of entry into the light chamber (h) for the light–dark transition test. i–l Distance traveled (i), total number of arm entries (j), percentage of entries into the open arms (k), and percent time spent in the open arms (l) for the elevated plus-maze test. All data are means ± SEM (WT mice, n = 22; PRT^–/– mice, n = 17 for a–h and n = 15 for i–l). P values for differences between genotypes were determined by two-way repeated-measures ANOVA (a–d) Student's t test (e, g, i–l), or Wilcoxon rank sum test (f, h). The results of all statistical analysis are provided in Additional file 1: Table S1