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Fig. 6 | Molecular Brain

Fig. 6

From: Protrudin-deficient mice manifest depression-like behavior with abnormalities in activity, attention, and cued fear-conditioning

Fig. 6

Depression-like behavior, startle response, and prepulse inhibition in protrudin-deficient mice. a–d Percentage immobility time (a, b) and distance traveled (c, d) on day 1 and day 2 for mice at 12 to 17 weeks of age (a, c) and the same mice at 56 to 66 weeks of age (b, d) in the Porsolt forced-swim test. e, f Startle amplitude (A.U., arbitrary units) (e) and prepulse inhibition (f) in the startle-response and prepulse-inhibition test. All data are means ± SEM (WT mice, n = 22; PRT–/– mice, n = 17). P values for differences between genotypes were determined by two-way repeated-measures ANOVA (a–d) or Student's t test (e, for 110 dB; f, for 74–120 dB and 78–120 dB), Welch t test (e, for 120 dB), or Wilcoxon rank sum test (f, for 74–110 dB and 78–110 dB). The results of all statistical analysis are provided in Additional file 1: Table S1

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