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Fig. 2 | Molecular Brain

Fig. 2

From: Focal loss of the paranodal domain protein Neurofascin155 in the internal capsule impairs cortically induced muscle activity in vivo

Fig. 2

Cortically evoked EMGs in NfasccKO and Nfasc+/+ mice injected with AAV5-EGFP-2A-Cre. a Representative EMGs in response to electrical stimulation (0.6 mA, 100 μs duration, single pulse, 1400 ms interval, averaged 100 times) of the motor cortex in Nfasc+/+ mice 12 weeks after AAV injection. Onset latency, peak latency and half-width of the EMGs are indicated. Amplitude of the EMGs is defined as the area over the mean during the response exceeding the level of the mean + 2SD (blue area, see also “Materials and methods”). Cortically evoked population EMGs of Nfasc+/+ (n = 5, blue line) and NfasccKO (n = 7, red line) at week 0 (b), 7 (c), 10 (d) and 13 (e). The light-shaded colors represent ± SEM. Ratio (%) of onset latency (f), peak latency (g), half-width (h) and amplitude (i) of cortically evoked EMGs in NfasccKO mice compared to those of Nfasc+/+mice before (week 0) and after (from week 1 to week 13) AAV injection (two-way ANOVA followed by Sidak multiple comparison test; onset latency (genotype [F (1,137) = 21.41, **p < 0.01], week [F (13,137) = 2.480, **p < 0.01], genotype × week [F (13,137) = 2.480, **p < 0.01]), peak latency (genotype [F (1,125 = 20.19, **p < 0.01), week [F (13,125) = 1.179, p = 0.3024], genotype × week [F (13,125) = 1.179, p = 0.3024]], half-width (genotype [F (1,127) = 9.162, **p < 0.01], week [F (13,127) = 0.8992, p = 0.5558], genotype × week [F (13,127) = 0.9034, p = 0.5515]), amplitude (genotype [F (1,126) = 3.182, p = 0.0769], week [F (13,126) = 0.4220, p = 0.9595], genotype × week [F (13,126) = 0.4221, p = 0.9594])). All data are expressed as mean ± SEM

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