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Fig. 5 | Molecular Brain

Fig. 5

From: Altered striatal dopamine levels in Parkinson’s disease VPS35 D620N mutant transgenic aged mice

Fig. 5

HPLC analysis of DA and its metabolites in the striatum of 22-months-old mice. a HPLC analysis of DA levels in the striatum normalized to the NTg group (mean ± SEM). DA levels were significantly (P = 0.028) higher in Tg mice (n = 7) than in age-matched NTg counterparts (n = 9); *p < 0.05, Student’s t-test. b HPLC analysis of DOPAC levels in the striatum normalized to the NTg group (mean ± SEM). DOPAC is a DA metabolite. No significant difference (P = 0.410) was observed in DOPAC levels between NTg (n = 9) and Tg mice (n = 7). c HPLC analysis of HVA levels in the striatum normalized to the NTg group (mean ± SEM). HVA is another metabolite of DA. No significant difference (P = 0.701) was observed in HVA levels between NTg (n = 5) and Tg mice (n = 6). d Metabolism rate normalized to the NTg group (mean ± SEM). The (DOPAC + HVA)/DA ratio is used as an indicator of the rate of DA turnover. There was no significant difference (P = 0.712) observed between NTg (n = 9) and Tg mice (n = 7). Student’s t-test

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