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Fig. 1 | Molecular Brain

Fig. 1

From: The novel multiple sclerosis susceptibility gene ATXN1 regulates B cell receptor signaling in B-1a cells

Fig. 1

Ataxin-1 controls immunoglobulin transcription and antigen presentation in B-1a cells. a Venn diagrams showing the overlap of DEGs between Atxn1-null and wildtype B-1a cells in both cross-sectional and longitudinal comparisons. b Unsupervised clustering of the DEGs separates Atxn1-null and wildtype B-1a cells at baseline and 10 days post-immunization (dpi) with MOG peptide (heatmaps on the left). Clustering also separates B-1a cells between baseline and post-immunization conditions within each genotype (heatmaps on the right). c Histograms showing the significant GO terms associated with cross-sectional comparisons at baseline and 10 dpi. d Histograms showing the significant GO terms associated with the Atxn1-null and wildtype specific DEGs from longitudinal comparisons. Significant GO terms enriched in up-regulated genes are depicted in orange, while the GO terms enriched in down-regulated genes are depicted in blue. Asterisks indicate the GO terms that passed multiple comparison correction (Q values less than 0.05)

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