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Fig. 1 | Molecular Brain

Fig. 1

From: Conditional knock out of transcription factor CTCF in excitatory neurons induces cognitive deficiency

Fig. 1

Touch screen analysis of behavioral phenotypes showed cognitive impairments in CTCF cKO mice. a PD reversal accuracy (i.e., correct response) rate. b Linear regression between correct response rate and time in the PD reversal leaning. c Comparison of reversal learning rate per day (%) between control and cKO mice. Individual dots represent data from individual animals. d Accuracy rate of different paired-associate learning (dPAL) touch screen test trials was measured after habituation and pre-training. In the dPAL test, adult CTCF cKO mice showed a moderate cognitive impairment. *p < 0.05, #p < 0.05. e Time course of learning phase during dPAL test. Note that the number of correction trial is decreased more rapidly in the controls than in cKO mice which showed no difference in the number of correction trial from day 1 to day 18. *p < 0.05, #p < 0.05

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