Fig. 2
From: Neurodegenerative phosphoprotein signaling landscape in models of SCA3
Side-by side comparison of signaling in reaction to the presence of wild-type and expanded ataxin-3 in MEF cells (a) and SCA3 mouse brain (b). Shown are the relative protein levels of signaling proteins altered upon the presence of wild-type ataxin-3 (comparison of MEFKO with MEFwt) or expanded ataxin-3 (MEF148Q vs. MEFwt) in MEF cells (a) as well as in mouse brain (SCA3 vs. wt mouse brain, b). Proteins are grouped according their stimulation (↑) / suppression (↓) by wild-type (ataxin-3wt) and expanded ataxin-3 (ataxin-3exp). For clarity, only the protein pairs displaying alterations of more that ± 20% in one or both proteins relative to the corresponding control levels are shown