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Fig. 4 | Molecular Brain

Fig. 4

From: 2-Pentadecyl-2-oxazoline ameliorates memory impairment and depression-like behaviour in neuropathic mice: possible role of adrenergic alpha2- and H3 histamine autoreceptors

Fig. 4

Effect of the chronic treatment with vehicle (kolliphor 5% in saline, v/v, i.p.) or PEA-OXA (10 mg/kg, i.p.) on pain and depression-like behavior in sham and SNI mice. a The timeline of the sham or SNI surgery, behavioral, microdialysis, electrophysiology experiments and vehicle or PEA-OXA chronic treatment. b The effect of the chronic treatment with vehicle or PEA-OXA on mechanical allodynia. c, d The effect of vehicle or PEA-OXA on duration of immobility in the forced swimming or tail suspension tests, respectively. Experiments have been carried out 30 days after SNI or sham surgery. Each point represents the mean ± S.E.M. Two-way ANOVA or RM Two-way ANOVA, followed by Tukey's post hoc test for multiple comparisons test was used for statistical analysis. p < 0.05 was considered statistically significant. Symbols indicate significant differences: *vs Sham/veh (p < 0.05), ***vs Sham/veh (p < 0.001), ****vs Sham/veh (p < 0.0001), #vs SNI/veh (p < 0.05), ###vs SNI/veh (p < 0.001), ####vs SNI/veh (p < 0.0001), respectively

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