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Fig. 5 | Molecular Brain

Fig. 5

From: Interleukin-17 induced by cumulative mild stress promoted depression-like behaviors in young adult mice

Fig. 5

Anti-IL-17 reduced anxiety- and depression-like behavior in CPMS mice. Mice were injected with an anti-IL-17 or IgG (total 5 times for 2 weeks) after cumulative mild stress. a Experimental scheme included behavior tests in the CPMS mice model after anti-IL-17 treatment. After treatment, 8-week-old mice were subjected to b EPM (CTL + IgG (n = 8); 81.63 ± 4.468, CTL + Anti-IL-17 (n = 6); 89.00 ± 1.528, CPMS + IgG (n = 8); 96.63 ± 1.253, CPMS + Anti-IL-17 (n = 7) 82.29 ± 4.799), c FST (CTL + IgG; 177.8 ± 6.256, CTL + Anti-IL-17; 182.4 ± 8.552, CPMS + IgG; 287.3 ± 14.00, CPMS + Anti-IL-17, 215.7 ± 6.707), and d SPT (CTL + IgG; 87.38 ± 1.721, CTL + Anti-IL-17; 87.86 ± 2.198, CPMS + IgG; 63.50 ± 7.273, CPMS + Anti-IL-17; 81.43 ± 3.176). Data are expressed as mean ± SEM. *p < 0.05, ***p < 0.001, ****p < 0.0001 vs. CTL + IgG; &&p < 0.01, &&&&p < 0.0001 vs. CTL + anti-IL-17; #p < 0.05, ###p < 0.001 vs.; CPMS + IgG

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Molecular Brain

ISSN: 1756-6606