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Fig. 5 | Molecular Brain

Fig. 5

From: Conditional Pten knockout in parvalbumin- or somatostatin-positive neurons sufficiently leads to autism-related behavioral phenotypes

Fig. 5

PV-Pten-KO mice showed anxiolytic behaviors while Sst-Pten-KO mice displayed anxiety-like behaviors, compared to their WT mice. a The schematic diagram of the elevated plus-maze test (EPM). b The schematic diagram of the center (blue) and corner area (orange) in the open field test. c PV-Pten-KO mice spent more percentage of time in the open arms compared to PV-Pten-WT and PV-Pten-Het mice (WT: n = 26, Het: n = 17, KO: n = 24; F(2,64) = 7.373, p = 0.001, one-way ANOVA; KO vs. WT: p = 0.005, Tukey’s post hoc test). d PV-Pten-KO mice spent less percentage of time in the closed arms compared to PV-Pten-WT and PV-Pten-Het mice (F(2,64) = 5.310, p = 0.007, one-way ANOVA; KO vs. WT: p = 0.023, Tukey’s post hoc test). e, f In the open field test, PV-Pten-KO mice spent more time in the center area (e) and less time in the corner area (f), compared to PV-Pten-WT mice (WT: n = 25, Het: n = 17, KO: n = 26; Center: p = 0.024, one-way ANOVA; KO vs. WT: p = 0.023, Tukey’s post hoc test; Corner: p = 0.016, Kruskal–Wallis test; KO vs. WT: p = 0.009, Dunn’s post hoc test). g Sst-Pten-KO mice spent less percentage of time in the open arms compared to Sst-Pten-WT mice (WT: n = 11, Het: n = 16, KO: n = 17; F(2,34) = 3.984, p = 0.028, one-way ANOVA; KO vs. WT: p = 0.026, Tukey’s post hoc test). h Sst-Pten-KO mice spent more percentage of time in the closed arms compared to Sst-Pten-WT mice (F(2,34) = 3.596, p = 0.038, one-way ANOVA; KO vs. WT: p = 0.031, Tukey’s post hoc test). i, j In the open field test, there was no difference in time spent in the center (i) or corner area (j) among the three genotypes of Sst-Pten mice (WT: n = 12, Het: n = 16, KO: n = 19; Center: p = 0.851, Kruskal–Wallis test; Corner: p = 0.502, Kruskal–Wallis test). Circles represent data from individual animals, and bar graphs indicate mean + SEM. *: significant; n.s.: not significant

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