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Fig. 1 | Molecular Brain

Fig. 1

From: Further evidence that CP-AMPARs are critically involved in synaptic tag and capture at hippocampal CA1 synapses

Fig. 1

Evidence that wTBS before sTBS does not effectively trigger heterosynaptic metaplasticity. a Two-input experiment that shows that a wTBS (15 pulses) induces a small, persistent input-specific LTP (n = 8). In this and subsequent time-course plots the data are mean ± SEM and representative traces show the superimposition of baseline and potentiated fEPSPs (averages of 5 successive records at the times indicated by numbers). b Delivery of a sTBS to one input (filled circles) resulted in a small heterosynaptic LTP in the second input plus an enhanced LTP induced by a wTBS (open symbols; n = 11). c Delivery of a wTBS to one input (open circles) resulted in a small LTP that was not appreciably affected by a subsequent sTBS on the other input (n = 8). d Superimposition of the LTP induced by the wTBS illustrated in panels a and b. e Superimposition of the LTP induced by the wTBS illustrated in panels a and c. f Quantification of the level of LTP, 90 min post wTBS (wLTP) under conditions of no priming (grey bar and data points), sTBS before wTBS (S→W) (white) and wTBS before sTBS (W→S) (brown). The bar graphs present the mean data ± SEM (**p < 0.01) and the cumulative distribution plots present each individual result along with a dashed line to show each group mean

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