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Fig. 2 | Molecular Brain

Fig. 2

From: Mice with mutations in Trpm1, a gene in the locus of 15q13.3 microdeletion syndrome, display pronounced hyperactivity and decreased anxiety-like behavior

Fig. 2

Locomotor activity and anxiety-like behavior of Trpm1−/− mice. Light/Dark transition test; a total distance traveled, b time spent in light, c number of transitions, d latency of opposite side. n = 24 for both genotypes. Open field test; e total distance traveled, f time spent in center of the field, g number of vertical activities, h number of stereotypies. n = 24 for both genotypes. i Total distance traveled with treatment of MPH. n = 9 for WT + Saline, n = 9 for WT + 3 mg/mL MPH, n = 12 for WT + 10 mg/mL MPH, n = 11 for Trpm1−/−  + saline, n = 12 for Trpm1−/−  + 3 mg/mL MPH, n = 12 for Trpm1−/−  + 10 mg/mL MPH. Elevated plus maze test; j total distance traveled, k time spent on open arms, l number of entries into open arms, m and number of entries. n = 24 for both genotypes. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001; 3-way ANOVA followed by Tukey’s multi comparison test (a–d), repeated measures 2-way ANOVA (e–h), repeated measures 2-way ANOVA followed by Tukey’s multi comparison test (i), Student’s t test (j, l, m), Welch’s t test (k)

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