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Fig. 5 | Molecular Brain

Fig. 5

From: Mice with mutations in Trpm1, a gene in the locus of 15q13.3 microdeletion syndrome, display pronounced hyperactivity and decreased anxiety-like behavior

Fig. 5

Structural and biochemical abnormalities in Trpm1 –/– mice. Brain weight at 1 month old (a), n = 5 WT, 4 Trpm1–/– and 4 months old (b), n = 24 for both genotypes. c Expression of Trpm1 gene in WT brain. n = 4 for both genotypes. All amplification data were normalized with mean cycle threshold (Ct) value of WT whole brain group for ΔCt and normalized with β-actin for ΔCt. Trpm1 mRNA was not detectable in whole brain of Trpm1–/– mice. Quantification of monoamine neurotransmitters in the cerebellum at 4 months old; d dopaminergic, e noradrenergic, f serotonergic neurotransmitters, and their metabolites. DOPAC: 3,4-dihydroxyphenylacetic acid, 3-MT: 3-methoxytyramine, HVA: homovanillic acid, Ad: adrenaline, NM: normetanephrine, MHPG: 3-methoxy-4-hydroxyphenylglycol, 5-HIAA: 5-hydroxyindoleacetic acid. n = 24 for both genotypes. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001; Student’s t test or Welch’s t test

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