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Fig. 1 | Molecular Brain

Fig. 1

From: Interactions between the amygdala and medial prefrontal cortex as upstream regulators of the hippocampus to reconsolidate and enhance retrieved inhibitory avoidance memory

Fig. 1

Effects of inactivation of the amygdala, mPFC, or hippocampus on the induction of c-Fos expression. a–c Micro-infusion of LIDO into the amygdala (a VEH, n = 8, LIDO, n = 11), mPFC (b VEH, n = 9, LIDO, n = 9) or hippocampus (c VEH, n = 10, LIDO, n = 9). *p < 0.05; two-way repeated ANOVA followed by the post hoc Bonferroni test. d–f Experimental time-course and representative immunohistochemical staining of c-Fos-positive cells in the BA and IL from the indicated group. Scale bar, 100 μm. g–i c-Fos expression in the PL and IL of the mPFC, CA1, CA3, and DG regions of the hippocampus, and LA, BA, and CeA regions of the amygdala 90 min after the micro-infusion of LIDO or VEH into the amygdala (g), mPFC (h) or hippocampus (i). n = 7–15 for each group. *p < 0.05; two-way ANOVA followed by the post hoc Bonferroni test. ANOVA analysis of variance, BA basolateral, CeA central, DG dentate gyrus, IL infralimbic, LA lateral, LIDO lidocaine, No-react No reactivation, PR-LTM-1 post-reactivation long-term memory test-1, PR-LTM-2 post-reactivation long-term memory test-2, PL prelimbic, React Reactivation, VEH vehicle. Error bars, standard error of the mean. The results of the statistical analyses are presented in Additional file 1

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