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Fig. 5 | Molecular Brain

Fig. 5

From: Enhanced contextual fear memory in peroxiredoxin 6 knockout mice is associated with hyperactivation of MAPK signaling pathway

Fig. 5

Proteomic analysis revealed differential expression proteins (DEPs) MAPK and Ras signaling pathways in the hippocampus of Prdx6−/− mice during retrieval of contextual fear memory. a Functional protein–protein interaction networks of 15 proteins related to GO term "protein phosphorylation" (GO:0006468). The significant nodes were labeled in red for Neurotrophin signaling pathway (FDR 0.00012), blue for the Ras signaling pathway (FDR 0.00073), and green for the MAPK signaling pathway (FRD 0.0011). b Heatmap of 15 proteins in GO term "protein phosphorylation" (GO:0006468) with 8 upregulated proteins and 7 down-regulated proteins in Prdx6−/− mice. c STRING showed a predicted functional protein–protein interaction network of proteins in the KEGG pathway termed "MAP kinase signaling pathway" with memory-associated proteins and PRDX6. The significant nodes were labeled in red for the MAPK signaling pathway (FDR 1.25e−12) and green for the Ras signaling pathway (FDR 3.33e−11)

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