Fig. 3
From: AMPAkines potentiate the corticostriatal pathway to reduce acute and chronic pain
AMPAkine in the NAc partially reconstitutes the anti-nociceptive effects of PL on chronic inflammatory pain. a CFA treatment induces mechanical allodynia, compared with saline-treated rats. CFA group, n = 12; Saline group, n = 13; ****p < 0.0001, Two-way ANOVA with repeated measures and Bonferroni’s multiple pair-wise comparisons. b AMPAkine infusion into the NAc core and activation of PL did not change mechanical hypersensitivity in control rats. ChR2 group, n = 7; YFP group, n = 6; ChR2 vs YFP, after AMPAkine infusion (p > 0.9999), after saline infusion (p = 0.2760); AMPAkine vs saline, in ChR2 rats (p > 0.9999), in YFP rats (p = 0.3044); Two-way ANOVA with repeated measures and Bonferroni’s multiple pair-wise comparisons. c Optogenetic activation of the PL has greater impact than AMPAkine potentiation of the NAc core on the reduction of sensory withdrawal. ChR2 group, n = 6; YFP group, n = 6; ChR2 vs YFP, after AMPAkine infusion (**p = 0.0025), after saline infusion (****p < 0.0001); AMPAkine vs saline, in ChR2 rats (p > 0.9999), in YFP rats (*p = 0.0340); Two-way ANOVA with repeated measures and Bonferroni’s multiple pair-wise comparisons