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Fig. 3 | Molecular Brain

Fig. 3

From: The Ser19Stop single nucleotide polymorphism (SNP) of human PHYHIPL affects the cerebellum in mice

Fig. 3

Abnormal PC morphology in PHY2S19X/S19X cerebellum. a, b Sagittal sections of P21 wild-type (WT) (a) and PHY2S19X/S19X (S19X/S19X) (b) mouse cerebella immunolabeled with an anti-calbindin antibody. Scale bars: 50 µm. c Cell densities of calbindin-positive PCs for WT (white, n = 40) and PHY2S19X/S19X (black, n = 71) mice at P21. d PC soma size for WT (white, n = 315) and PHY2S19X/S19X (black, n = 289) mice at P21. e Longitudinal diameter (height) of the PC soma for WT (white, n = 124) and PHY2S19X/S19X (black, n = 106) mice at P21. f Transversal diameter (width) of the PC soma for WT (white, n = 124) and PHY2S19X/S19X (black, n = 106) mice at P21. P = 0.0314, Student’s t test. g Height/width ratio of the PC soma for WT (white, n = 124) and PHY2S19X/S19X (black, n = 106) mice at P21. P = 0.00424, Student’s t test. The error bars indicate the s.e.m. *P < 0.05; **P < 0.01; ***P < 0.001, Student’s t test

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