Fig. 8From: The C. elegans homolog of human panic-disorder risk gene TMEM132D orchestrates neuronal morphogenesis through the WAVE-regulatory complexModel. In wild-type cells, TMEM132 family proteins function as local F-actin regulators by sequestrating Nap/Sra homologs and thus limiting the abundance of WRC because of disintegration/degradation of other WRC components. Consequently, there is limited cell morphological changes at cell surface compartments where TMEM132 proteins are enriched and WRC/F-actin nucleating activity is restricted. In TMEM132 deficient cells, Nap/Sra proteins are not sequestered and thus WRC is intact, permitting WRC/F-actin-nucleating activity that is normally regulated by Rho-GTPases and other factors in response to membrane signalingBack to article page