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Fig. 1 | Molecular Brain

Fig. 1

From: SGTA associates with intracellular aggregates in neurodegenerative diseases

Fig. 1

SGTA colocalized with polyQ aggregates in HD model cells. a Immunocytochemistry of Huntington disease (HD) model cells, HD150Q cells or HD 150QNLS cells. PolyQ aggregate formation was induced in these cells. Endogenous small glutamine-rich tetratricopeptide repeat (TPR)-containing protein alpha (SGTA) was labeled with anti-SGTA antibody (secondary antibody: Alexa Fluor 546). The nuclei were stained with 4′,6-diamidino-2-phenylindole (DAPI). Scale bar = 20 μm. b Cell lysates of Neuro2a wild type (WT), HD16Q, and HD150Q cells were fractionated into soluble and insoluble fractions. Immunoblotting with anti-SGTA, anti-LaminB and anti-1C2 antibodies was performed

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