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Fig. 2 | Molecular Brain

Fig. 2

From: Correction to: 2-Pentadecyl-2-oxazoline ameliorates memory impairment and depression-like behaviour in neuropathic mice: possible role of adrenergic alpha2- and H3 histamine autoreceptors

Fig. 2

Structural alignment used for model building. Ballesteros–Weinstein numbers are used to label the most conserved residues within transmembrane helices, highlighted in cyan. Conserved cysteine residues involved in disulfide bridge are colored in yellow. The negatively charged residues Asp144 and Glu206 critical for histamine binding are colored in red while Arg381, proposed as relevant for PEA-OXA binding is colored in green. The long loop i3 was truncated in the model, leaving only the residues allowing a proper linker between the helices. The transmembrane helices H1–H8 are underlined while the intracellular and extracellular loops are labeled “i1–3” and “e1–3”, respectively

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