Fig. 6
From: Palmitate reduces starvation-induced ER stress by inhibiting ER-phagy in hypothalamic cells
A schematic diagram illustrating the different roles of palmitate in ER-phagy and ER stress under nutrient-rich and starvation conditions. Palmitate induces p-PERK-mediated ER stress and autophagy, but prolonged treatment with palmitate impairs autophagy under nutrient-rich conditions. EBSS-induced starvation increases ER-phagy and ER stress, and ER-phagy precedes ER stress under these circumstances. Palmitate inhibits ER-phagy by increasing Bcl-2 and also decreases ER stress under EBSS-induced starvation