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Fig. 3 | Molecular Brain

Fig. 3

From: Lack of the peroxiredoxin 6 gene causes impaired spatial memory and abnormal synaptic plasticity

Fig. 3

Decline of hippocampal LTP in Prdx6−/− mice recorded from basal condition. a Schematic representation of LTP depicting stimulation and recording in hippocampal CA1-CA3 synapse. b Input–output curve of fEPSP slope (n = 8 slices/5 mice in each group). c Average fEPSP plotted against time in minutes (n = 5 mice/group). d Example traces representing the average of 3 sweeps. e–g The average of fEPSP slopes from the last 10 min of the first hour and third hour after HFS of Prdx6+/+ and Prdx6−/− mice were calculated and plotted. Normalized fEPSP slope (%) for baseline (e), first hour (f) and third hour (g) of hippocampal LTP. All data are presented as mean ± SEM. #p < 0.05. Unpaired Student’s t test following a normal distribution and mixed-design repeated measure ANOVA followed by Bonferroni’s post hoc test with unpaired Student’s t test for individual differences between groups within training day

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