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Fig. 1 | Molecular Brain

Fig. 1

From: Repeated infusion of mesenchymal stem cells maintain the condition to inhibit deteriorated motor function, leading to an extended lifespan in the SOD1G93A rat model of amyotrophic lateral sclerosis

Fig. 1

a Experimental protocol. b Kaplan–Meier estimates of mean survival of ALS rats. The MSC-4 group showed significantly prolonged survival using the log-rank test and Holm post-hoc test. Log-rank, p = 0.005. The number of surviving rats at each timer point are shown in Additional file 1: Table S1. c Basso-Beattie-Bresnahan (BBB) scores, excluding the rats that reached the endpoint (BBB score 0). The number of surviving rats at each timer point are shown in Additional file 1: Table S2. d BBB scores including the rats that reached the endpoint (BBB score 0) as zero. Arrows indicate the points of infusion. (n = 6/groups). e Required days to reach a BBB score of 7 (from BBB score 15). (n = 6/groups). f Body weight of all surviving animals. (n = 6/groups). *p < 0.05, **p < 0.01. Data are presented as mean ± SEM. MSCs mesenchymal stem cells, BBB Basso, Beattie, and Bresnahan, SEM standard error of the mean

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Molecular Brain

ISSN: 1756-6606