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Fig. 2 | Molecular Brain

Fig. 2

From: Serotonergic gene-to-gene interaction is associated with mood and GABA concentrations but not with pain-related cerebral processing in fibromyalgia subjects and healthy controls

Fig. 2

Extracted BOLD-signal and GABA concentration. Fibromyalgia subjects (FMS) (n = 68) showed a similar pattern of lower pain-evoked BOLD-signal as healthy controls (HC) (n = 33) in a right rACC and b bilateral thalamus. This effect, however, was only significant in thalamus. c In thalamic GABA concentrations (FMS = 74, HC = 42), there was a significant 5‐HT1A-by-5-HTT interaction, as well as a significant group-by-5-HTT interaction. A comparable pattern was observed in both relative (upper row) and absolute GABA (lower row) concentrations. Plotted are black circles, triangles and squares representing estimated marginal means with the associated black vertical lines being 95% confidence intervals. In the colored boxplots, the horizontal line represents the median, the upper and lower box representing the 25th (Q1) and 75th (Q3) percentile, i.e. the interquartile range (IQR), and whiskers represent Q1− and Q3 + 1.5*IQR. Raw data is plotted in the background. a.u. arbitrary units, mM millimole, L left, R right

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Molecular Brain

ISSN: 1756-6606