Serotonergic gene-to-gene interaction is associated with mood and GABA concentrations but not with pain-related cerebral processing in fibromyalgia subjects and healthy controls

Table 4 ANOVAs for relative and absolute glutamate and GABA concentrations in thalamus

	Effect	df_Num, df_Den	MSE	F	η²_G	p
Relative glutamate
	Group	1, 101	1.84	0.55	0.005	0.460
	5‐HT_1A	1, 101	1.84	1.16	0.011	0.283
	5-HTT	2, 101	1.84	0.20	0.004	0.820
	Group*5‐HT_1A	1, 101	1.84	0.15	0.001	0.703
	Group*5‐HTT	2, 101	1.84	0.12	0.002	0.890
	5‐HT_1A*5‐HTT	2, 101	1.84	0.51	0.010	0.603
Relative GABA
	Group	1, 101	0.73	0.34	0.003	0.563
	5‐HT_1A	1, 101	0.73	6.05	0.047	0.016
	5-HTT	2, 101	0.73	1.19	0.019	0.308
	Group*5‐HT_1A	1, 101	0.73	1.35	0.011	0.247
	*Group5‐HTT**	2, 101	0.73	4.67	0.073	0.011
	5‐HT_1A*5‐HTT	2, 101	0.73	3.60	0.056	0.031
Absolute glutamate
	Group	1, 101	1.65	0.10	< 0.001	0.748
	5‐HT_1A	1, 101	1.65	0.29	0.003	0.592
	5-HTT	2, 101	1.65	0.40	0.008	0.669
	Group*5‐HT_1A	1, 101	1.65	0.16	0.001	0.693
	Group*5‐HTT	2, 101	1.65	0.50	0.009	0.611
	5‐HT_1A*5‐HTT	2, 101	1.65	1.01	0.019	0.367
Absolute GABA
	Group	1, 101	0.70	0.59	0.005	0.442
	5‐HT_1A	1, 101	0.70	6.23	0.047	0.014
	5-HTT	2, 101	0.70	1.47	0.022	0.236
	Group*5‐HT_1A	1, 101	0.70	1.47	0.011	0.228
	*Group5‐HTT**	2, 101	0.70	5.81	0.089	0.004
	5‐HT_1A*5‐HTT	2, 101	0.70	3.63	0.055	0.030

df_Num numerator degree of freedom, df_Den denominator degrees of freedom, MSE mean square error, η²_G generalized eta-squared. Effects significant at p < 0.05 are depicted in bold

ISSN: 1756-6606