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Fig. 4 | Molecular Brain

Fig. 4

From: Impact of Gba2 on neuronopathic Gaucher’s disease and α-synuclein accumulation in medaka (Oryzias latipes)

Fig. 4

Gba1 and Gba2 deficiency caused asyn accumulation in the medaka brains. a, b Immunoblot analysis of asyn in the brains at 3 mpf. Asyn was increased in the gba1 KO, gba2 KO and gba1/gba2 DKO medaka compared with WT medaka (n = 6 for each genotype). NSE was used as a loading control. A one-way ANOVA Newman-Keuls multiple comparison test was performed. The bars indicate the mean ± SEM. n.s. not significant, *p < 0.05, c Asyn immunohistochemical staining of the diencephalon at 3 mpf. Asyn accumulations (arrowheads) were observed in gba1 KO and gba1/gba2 DKO medaka but not in gba2 KO medaka or WT medaka

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