Skip to main content
Fig. 6 | Molecular Brain

Fig. 6

From: Impact of Gba2 on neuronopathic Gaucher’s disease and α-synuclein accumulation in medaka (Oryzias latipes)

Fig. 6

Proposed mechanisms of deletion of Gba1 and Gba2 leading to asyn accumulation. Deletion of Gba1 and Gba2 induces changes in the sphingolipid metabolism. These changes might induce conformational changes in asyn, resulting in asyn accumulation. Furthermore, the deletion of Gba1 causes autophagic dysfunction, resulting in the impairment of asyn degradation and leading to asyn accumulation. The solid and striped arrows indicate the downstream pathways of gba1 KO and gba2 KO, respectively

Back to article page