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Fig. 8 | Molecular Brain

Fig. 8

From: Cdk5 regulatory subunit-associated protein 1 knockout mice show hearing loss phenotypically similar to age-related hearing loss

Fig. 8

Early apoptosis, ROS generation, and senescence in Cdk5rap1-KO cells. a, b Proportion of senescent cells (blue) in Cdk5rap1-knockout (KO) and littermate control (CNT) cell passages (P2–5) (n = 5 for each genotype) (c–f) Proportion of c, d ROS-positive (green fluorescence, white arrows) and e, f TUNEL-positive (green fluorescence, white arrows) cells in each subculture of KO and CNT cells. (ROS: n = 5 for each genotype, TUNEL: n = 3 for each genotype); Scale bar = 100 µm

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