Fig. 5

Differences in conduction velocity and response kinetics in different neuron types based on stimulation location. A Averaged rise and decay times based either on long distance (long) or short distance (short), and either on deep layer or superficial layer stimulation (left) and averaged conduction velocities for the same groups (right) for pyramidal neurons. There were no differences between rise and decay time when looking at long/short distance and deep/superficial layer stimulations. Conduction velocity was found to be larger in long distance stimulations in pyramidal neurons (long distance: 0.13 ± 0.007 m/s; short distance: 0.1 ± 0.01 m/s; *p < 0.05; Welch t-test). B Shows the same type of data was gathered for fast-spiking interneurons as (A) for fast-spiking interneurons. Differences in decay time between long/short distance and deep/superficial layer stimulations were found to be statistically significant (long distance: 29.1 ± 7.2 ms; short distance: 51.5 ± 10.5 ms; deep layer: 22.2 ± 7.5 ms; superficial layer: 49.4 ± 8.6; *p < 0.05; Welch t-test). Differences in rise time as well as conduction velocity between long/short distance and deep/superficial layer were found to be not significant. C Shows the same type of data was gathered for fast-spiking interneurons as (A) for regular-spiking interneurons. Differences in rise/decay times and conduction velocity when comparing long/short distance and deep/superficial layers were found to be not significant in regular-spiking interneurons. All presented data were collected under the same conditions and averaged according to their respective categories (PN: n = 45 channels/8 neurons; FS IN: n = 30 channels/4 neurons; RS IN: 18 channels/3 neurons). Error bars represent SEM