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Fig. 3 | Molecular Brain

Fig. 3

From: In vivo imaging of immediate early gene expression dynamics segregates neuronal ensemble of memories of dual events

Fig. 3

Quantification of behaviourally induced cfos-shGFP fluorescence describing the protein expression profile fits well to derived equation (Eq. 1). indicating that the analytical equation generalises to different fluorophore constructs. a Images from the RSc region of the cfos-shGFP transgenic mice reveal the circular bright nuclei at 90 min. The image is one of the 200 × 200 microns optical section. The scale bar represents 20 microns. b Four representative image ROIs centred around cells “#501”, “#486”, “#475” and “#430” in cfos-shGFP transgenic mice across different time points respectively. c Are the corresponding quantitative measure of cellular expression profile of cells in b along with their fits to Eq. 1. The open circles represent the amplitude of the cellular activity from a neuron at a given time. The red line is the fit of this data to Eq. 1. A good agreement of the fit to the observed data (Adj. R Sq > 0.79) indicates that our model is consistent with the observed cellular response. Blue dotted line extends the fits and spans the entire x-axis as explained in Fig. 2. See Table 2 for fit parameters

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