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Fig. 4 | Molecular Brain

Fig. 4

From: Reductions in midbrain GABAergic and dopamine neuron markers are linked in schizophrenia

Fig. 4

GABAA alpha 3 subunit gene expression in the midbrain of control and schizophrenia cases. a GABRA3 mRNA was 21.98% lower in patients with schizophrenia relative to controls. b Reductions in GABRA3 mRNA were exacerbated in the high inflammatory/schizophrenia subgroup. GABRA3 mRNA was lower in high inflammatory/schizophrenia cases compared with both low inflammatory/schizophrenia cases and controls. There was no difference in GABRA3 mRNA between low inflammatory/schizophrenia cases compared with controls. c A GABAA α3 subunit protein band was detected at ~ 55 kDa in human midbrain by an antibody raised against amino acids 6–125. β-actin (42 kDa) was used as a loading control. d GABRA3 protein was 23.24% lower in schizophrenia cases relative to controls, though this change did not reach statistical significance. Pink dots are low inflammatory/schizophrenia cases, dark red dots are high inflammatory/schizophrenia cases. SCZ schizophrenia, IC internal control, C control, SH schizophrenia high inflammatory, SL schizophrenia low inflammatory. Statistical results for analysis by inflammatory subgroup are also in Table 3. Bars indicate mean ± SEM. **p < 0.01., ****p < 0.0001

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