Fig. 5

GABA_A alpha 3 subunit expression was abundant in dopaminergic neurons in the midbrain. a Double-labelling immunohistochemistry revealed GABRA3⁺/TH⁺ neurons with variable levels of GABRA3 (yellow arrowheads) and GABRA3⁺/TH⁻ cells (white arrowhead) in the substantia nigra. GABRA3 expression was identified along the cell membrane and processes (b) and in the cytoplasm of TH⁺ neurons (c). GABRA3⁺/TH⁻ cells (d) and GABRA3⁻/TH⁺ neurons (e) were occasionally identified in the midbrain in schizophrenia and controls cases. Scale bars = 50 μm (a) and 20 μm (b–e)