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Fig. 6 | Molecular Brain

Fig. 6

From: Reductions in midbrain GABAergic and dopamine neuron markers are linked in schizophrenia

Fig. 6

TH and DAT gene expression in the midbrain of controls and schizophrenia cases, and the relationships between TH and GABRA2 and GABRA3 mRNAs in the midbrain in control and schizophrenia cases. a TH mRNA and b DAT mRNA levels in the midbrain were significantly lower in the schizophrenia group relative to the controls. c TH and GABRA2 mRNAs were not correlated in controls, d but were strongly positively correlated in schizophrenia cases. The strength of these correlations was significantly different (z = − 3.13, p = 0.002) . Similarly, TH and GABRA3 mRNA were not significantly correlated in controls, e but were strongly positively correlated in schizophrenia cases (f). The strength of these correlations was significantly different (z = − 3.04, p = 0.002). Pink dots are low inflammatory/schizophrenia cases, dark red dots are high inflammatory/schizophrenia cases. Bars indicate mean ± SEM. *p < 0.05., ***p < 0.001

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