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Fig. 5 | Molecular Brain

Fig. 5

From: Reversibility of motor dysfunction in the rat model of NGLY1 deficiency

Fig. 5

Intracerebroventricular AAV9-hNGLY1 administration partly attenuated astrogliosis in thalamic VPL/VPM regions of Ngly1−/− rats. a Immunohistochemistry for GFAP and IbaI in the thalamus of virus-injected WT and Ngly1−/− rats at 11 weeks of age. Scale bar = 0.1 mm. Nuclei were stained with DAPI. b, c Quantitative analyses show the area occupied by GFAP (b) or IbaI (c) positive areas in the thalamic VPL/VPM regions of virus-injected WT and Ngly1−/− rats. Values represent mean ± S.E.M. The number of rats examined is shown in parentheses. *P < 0.05. n.s. = no significance

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