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Fig. 2 | Molecular Brain

Fig. 2

From: A role for BDNF- and NMDAR-induced lysosomal recruitment of mTORC1 in the regulation of neuronal mTORC1 activity

Fig. 2

pS6 phosphorylation in dendrites. A Variability of neuronal responses to NMDAR stimulation. Shown is the distribution of P-pS6 signal (expressed as mean fluorescence intensity) of individual neuronal somas present in large field images in control or cLTP conditions (N = 439 control somas; N = 517 cLTP somas, 2 independent experiments). The red dotted line represents the 75th percentile of the distribution of the P-pS6 signal measured in control cells. B Selection of individual dendrites on a MAP2 epifluorescence image. Bar 50 µm. C Presence of active spots far from the soma along dendrites upon NMDAR stimulation. Shown is a representative example of plot line analysis of the P-pS6 signal along dendrites from a control neuron and a cLTP-treated one. Arrows indicate the P-pS6 spots observed in the stimulated dendrites and depicted in the corresponding graph. 20 dendrites from 10 neurons in 2 independent experiments for both conditions have been analyzed. Bar, 20 µm

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