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Table2 Pathway enrichment analysis for DEGs

From: Transcriptomic profiling of high- and low-spiking regions reveals novel epileptogenic mechanisms in focal cortical dysplasia type II patients

Pathway enrichment analysis

Source

Term_name

Term_id

Adjusted_p_value

Negative_log10_of_adjusted_p_value

Term_size

Query_size

Intersection_size

Effective_domain_size

Intersections

A: Maximum vs autopsy

GO:BP

Myelination

GO:0042552

0.00168791

2.77265077

139

43

6

17906

PLP1, MAG, UGT8, CD9, PLLP, SH3TC2

GO:BP

Ensheathment of neurons

GO:0007272

0.00191291

2.71830651

142

43

6

17906

PLP1, MAG, UGT8, CD9, PLLP, SH3TC2

GO:BP

Axon ensheathment

GO:0008366

0.00191291

2.71830651

142

43

6

17906

PLP1, MAG, UGT8, CD9, PLLP, SH3TC2

GO:BP

Oligodendrocyte development

GO:0014003

0.04500542

1.34673519

47

22

3

17906

PLP1, MAG, CD9

B: Maximum vs minimum

GO:BP

Ensheathment of neurons

GO:0007272

1.44E−11

10.8420434

142

158

17

17906

PLP1,KLK6,UGT8,CLDN11,ASPA,SH3TC2,MAG,NKX6-2,FA2H,CNTN2,TMEM98,CD9,GAL3ST1,ABCA2,PLLP,BCAS1,SOX10

GO:BP

Axon ensheathment

GO:0008366

1.44E−11

10.8420434

142

158

17

17906

PLP1,KLK6,UGT8,CLDN11,ASPA,SH3TC2,MAG,NKX6-2,FA2H,CNTN2,TMEM98,CD9,GAL3ST1,ABCA2,PLLP,BCAS1,SOX10

GO:BP

Myelination

GO:0042552

1.72E−10

9.76340897

139

158

16

17906

PLP1,KLK6,UGT8,ASPA,SH3TC2,MAG,NKX6-2,FA2H,CNTN2,TMEM98,CD9,GAL3ST1,ABCA2,PLLP,BCAS1,SOX10

GO:BP

Oligodendrocyte differentiation

GO:0048709

9.24E−09

8.03431166

101

158

13

17906

SLC45A3,PLP1,ASPA,MAG,NKX6-2,FA2H,CNTN2,TMEM98,CD9,ABCA2,BOK,DAAM2,SOX10

GO:BP

Axon ensheathment in central nervous system

GO:0032291

2.50E−08

7.60287967

23

158

8

17906

PLP1,ASPA,MAG,NKX6-2,FA2H,CNTN2,ABCA2,SOX10

GO:BP

Central nervous system myelination

GO:0022010

2.50E−08

7.60287967

23

158

8

17906

PLP1,ASPA,MAG,NKX6-2,FA2H,CNTN2,ABCA2,SOX10

GO:BP

Oligodendrocyte development

GO:0014003

4.89E−07

6.311047

47

158

9

17906

PLP1,ASPA,MAG,NKX6-2,FA2H,CNTN2,CD9,ABCA2,SOX10

GO:BP

Gliogenesis

GO:0042063

2.13039E−05

4.67154125

310

134

15

17906

LRP2,SLC45A3,PLP1,ASPA,SH3TC2,MAG,NKX6-2,FA2H,CNTN2,TMEM98,CD9,CERS2,ABCA2,BOK,DAAM2

GO:BP

Glial cell differentiation

GO:0010001

2.48143E−05

4.60529884

226

158

14

17906

SLC45A3,PLP1,ASPA,SH3TC2,MAG,NKX6-2,FA2H,CNTN2,TMEM98,CD9,ABCA2,BOK,DAAM2,SOX10

GO:BP

Glial cell development

GO:0021782

9.74491E−05

4.01122223

121

109

9

17906

PLP1,ASPA,SH3TC2,MAG,NKX6-2,FA2H,CNTN2,CD9,ABCA2

GO:BP

Sphingolipid biosynthetic process

GO:0030148

0.000460392

3.33687211

105

109

8

17906

UGT8,ELOVL1,PLPP2,FA2H,P2RX7,CERS2,GAL3ST1,ABCA2

GO:BP

Regulation of gliogenesis

GO:0014013

0.000494076

3.30620614

132

158

10

17906

LRP2,SLC45A3,ASPA,MAG,NKX6-2,CNTN2,TMEM98,CERS2,DAAM2,SOX10

GO:BP

Nervous system development

GO:0007399

0.000672174

3.17251812

2432

160

46

17906

LRP2,AQP1,SLC45A3,MOG,PLP1,KLK6,UGT8,CLDN11,SPP1,GLDN,GJB1,ASPA,MOBP,SH3TC2,C21ORF91,MAG,S1PR5,NKX6-2,FA2H,CNTN2,DOCK10,TMEM98,CD9,USH1C,SEMA4D,TNC,NDE1,CERS2,MYO1D,GAL3ST1,ABCA2,PLLP,ZNF536,SEMA6A,BOK,SYNJ2,SEMA3B,MAN2A1,BCAS1,DAAM2,KIF13B,WHRN,FRYL,SFRP1,SOX10,MAP4K4

GO:BP

Neurogenesis

GO:0022008

0.000902115

3.04473832

1679

166

37

17906

LRP2,SLC45A3,PLP1,KLK6,UGT8,SPP1,GLDN,ASPA,SH3TC2,C21ORF91,MAG,S1PR5,NKX6-2,FA2H,CNTN2,DOCK10,TMEM98,CD9,USH1C,SEMA4D,TNC,NDE1,CERS2,ABCA2,ZNF536,SEMA6A,BOK,SEMA3B,MAN2A1,DAAM2,KIF13B,WHRN,FRYL,SFRP1,SOX10,MAP4K4,LTK

GO:BP

Cell development

GO:0048468

0.000919176

3.03660132

2215

160

43

17906

LRP2,SLC45A3,PLP1,KLK6,UGT8,SPP1,GLDN,ASPA,TYMS,DYSF,SH3TC2,DOCK5,C21ORF91,MAG,S1PR5,LDB3,CAPN3,NKX6-2,FA2H,CNTN2,PIP4K2A,DOCK10,TMEM98,CD9,USH1C,SEMA4D,TNC,CERS2,ABCA2,TJP2,ZNF536,SEMA6A,SEMA3B,MAN2A1,CLIC4,CFL2,DAAM2,KIF13B,WHRN,FRYL,SFRP1,SOX10,MAP4K4

GO:BP

Regulation of glial cell differentiation

GO:0045685

0.001515404

2.81947151

73

79

6

17906

SLC45A3,ASPA,MAG,NKX6-2,CNTN2,TMEM98

GO:BP

Regeneration

GO:0031099

0.003378801

2.4712374

209

96

9

17906

KLK6,SPP1,TYMS,DYSF,MAG,CAPN3,CD9,TNC,CERS2

GO:BP

Ceramide biosynthetic process

GO:0046513

0.00370985

2.4306437

64

105

6

17906

UGT8,ELOVL1,FA2H,P2RX7,CERS2,GAL3ST1

GO:BP

Membrane lipid biosynthetic process

GO:0046467

0.005378894

2.26930705

145

109

8

17906

UGT8,ELOVL1,PLPP2,FA2H,P2RX7,CERS2,GAL3ST1,ABCA2

GO:BP

Negative regulation of neurogenesis

GO:0050768

0.006339891

2.19791821

303

160

13

17906

SPP1,MAG,NKX6-2,CNTN2,TMEM98,SEMA4D,CERS2,ZNF536,SEMA6A,SEMA3B,DAAM2,SOX10,MAP4K4

GO:BP

Galactosylceramide biosynthetic process

GO:0006682

0.007164655

2.14480471

6

105

3

17906

UGT8,FA2H,GAL3ST1

GO:BP

Galactolipid biosynthetic process

GO:0019375

0.007164655

2.14480471

6

105

3

17906

UGT8,FA2H,GAL3ST1

GO:BP

Regulation of neurogenesis

GO:0050767

0.007966259

2.09874557

856

166

23

17906

LRP2,SLC45A3,KLK6,SPP1,ASPA,C21ORF91,MAG,S1PR5,NKX6-2,CNTN2,TMEM98,SEMA4D,CERS2,ZNF536,SEMA6A,SEMA3B,MAN2A1,DAAM2,KIF13B,SFRP1,SOX10,MAP4K4,LTK

GO:BP

Cellular component morphogenesis

GO:0032989

0.010095286

1.99588137

1177

160

27

17906

LRP2,UGT8,ENPP2,SPP1,ERMN,DOCK5,CDH19,MAG,LDB3,CAPN3,CNTN2,P2RX7,DOCK10,CD9,SEMA4D,WIPF1,ABCA2,CDC42EP1,SEMA6A,SEMA3B,PHLDB1,CLIC4,CFL2,KIF13B,WHRN,FRYL,MAP4K4

GO:BP

Sphingolipid metabolic process

GO:0006665

0.011698213

1.93188047

161

109

8

17906

UGT8,ELOVL1,PLPP2,FA2H,P2RX7,CERS2,GAL3ST1,ABCA2

GO:BP

Negative regulation of nervous System development

GO:0051961

0.013118962

1.88210053

324

160

13

17906

SPP1,MAG,NKX6-2,CNTN2,TMEM98,SEMA4D,CERS2,ZNF536,SEMA6A,SEMA3B,DAAM2,SOX10,MAP4K4

GO:BP

Regulation of cell projection organization

GO:0031344

0.015838735

1.8002795

704

166

20

17906

ANLN,KLK6,ENPP2,SPP1,ERMN,C21ORF91,MAG,CNTN2,P2RX7,USH1C,SEMA4D,CERS2,PLD1,CDC42EP1,SEMA6A,SEMA3B,KIF13B,SFRP1,MAP4K4,LTK

GO:BP

System development

GO:0048731

0.018013177

1.74440968

5020

167

73

17906

LRP2,AQP1,SLC45A3,MOG,PLP1,ANLN,DMRT2,PCSK6,KLK6,UGT8,CLDN11,ENPP2,SPP1,GLDN,GJB1,ASPA,TYMS,TF,MOBP,DYSF,ELOVL1,SH3TC2,ADAMTS1,C21ORF91,MAG,S1PR5,LDB3,CAPN3,NKX6-2,FA2H,CNTN2,PIP4K2A,P2RX7,ATF3,DOCK10,TMEM98,CD9,CRYAB,USH1C,SEMA4D,TNC,NDE1,CERS2,MYO1D,TGFA,GAL3ST1,ABCA2,PLLP,ZNF536,RASSF2,SEMA6A,BOK,SYNJ2,SEMA3B,PHLDB1,MAN2A1,CLIC4,CFL2,BCAS1,DAAM2,KIF13B,WHRN,GLIPR2,FGF1,MCAM,FRYL,PLAAT3,SFRP1,SOX10,MAP4K4,COL5A2,LTK,CARTPT

GO:BP

Glycosylceramide biosynthetic process

GO:0046476

0.019890103

1.70136298

8

105

3

17906

UGT8,FA2H,GAL3ST1

GO:BP

Central nervous system development

GO:0007417

0.022798319

1.64209718

1031

158

24

17906

LRP2,AQP1,SLC45A3,MOG,PLP1,KLK6,UGT8,ASPA,C21ORF91,MAG,NKX6-2,FA2H,CNTN2,TMEM98,CD9,NDE1,MYO1D,ABCA2,BOK,SYNJ2,DAAM2,WHRN,SFRP1,SOX10

GO:BP

Lipid biosynthetic process

GO:0008610

0.023671623

1.62577197

711

155

19

17906

SLC45A3,PLP1,UGT8,ELOVL1,PLPP2,FA2H,SLC44A1,PIP4K2A,P2RX7,CYB5R2,CERS2,PLD1,GAL3ST1,ABCA2,ACSL1,SYNJ2,GPD1,FGF1,PLAAT3

GO:BP

Regulation of cell development

GO:0060284

0.027719447

1.55721544

991

166

24

17906

LRP2,SLC45A3,KLK6,SPP1,ASPA,DOCK5,C21ORF91,MAG,S1PR5,NKX6-2,CNTN2,TMEM98,SEMA4D,CERS2,ZNF536,SEMA6A,SEMA3B,MAN2A1,DAAM2,KIF13B,SFRP1,SOX10,MAP4K4,LTK

GO:BP

Positive regulation of bleb assembly

GO:1904172

0.028707127

1.54201028

2

71

2

17906

ANLN,P2RX7

GO:BP

Regulation of bleb assembly

GO:1904170

0.028707127

1.54201028

2

71

2

17906

ANLN,P2RX7

GO:BP

Galactosylceramide metabolic process

GO:0006681

0.029707822

1.52712919

9

105

3

17906

UGT8,FA2H,GAL3ST1

GO:BP

Negative regulation of cell development

GO:0010721

0.029857665

1.52494416

350

160

13

17906

SPP1,MAG,NKX6-2,CNTN2,TMEM98,SEMA4D,CERS2,ZNF536,SEMA6A,SEMA3B,DAAM2,SOX10,MAP4K4

GO:BP

Drug transmembrane transport

GO:0006855

0.032057254

1.49407368

75

2

2

17906

LRP2,AQP1

GO:BP

Generation of neurons

GO:0048699

0.033131105

1.47976408

1574

166

32

17906

LRP2,SLC45A3,PLP1,KLK6,UGT8,SPP1,GLDN,ASPA,C21ORF91,MAG,S1PR5,NKX6-2,CNTN2,DOCK10,TMEM98,USH1C,SEMA4D,TNC,NDE1,CERS2,ZNF536,SEMA6A,SEMA3B,MAN2A1,DAAM2,KIF13B,WHRN,FRYL,SFRP1,SOX10,MAP4K4,LTK

GO:BP

Ceramide metabolic process

GO:0006672

0.034955601

1.45648322

94

105

6

17906

UGT8,ELOVL1,FA2H,P2RX7,CERS2,GAL3ST1

GO:BP

Transmembrane transport

GO:0055085

0.038251324

1.41735353

1634

73

19

17906

LRP2,AQP1,PIEZO2,KCNH8,SLC45A3,ABCA8,TMEM144,GJB1,TF,SGK2,TMEM63A,DYSF,SLC5A11,CLCA4,TTYH2,CAPN3,SLC44A1,P2RX7,SLC26A9

GO:BP

Cellular component assembly involved in morphogenesis

GO:0010927

0.039919771

1.39881196

114

132

7

17906

UGT8,LDB3,CAPN3,CD9,ABCA2,PHLDB1,CFL2

GO:BP

Galactolipid metabolic process

GO:0019374

0.042258663

1.37408425

10

105

3

17906

UGT8,FA2H,GAL3ST1

GO:BP

Regulation of plasma membrane bounded cell projection organization

GO:0120035

0.045082781

1.3459893

694

166

19

17906

ANLN,KLK6,ENPP2,SPP1,C21ORF91,MAG,CNTN2,P2RX7,USH1C,SEMA4D,CERS2,PLD1,CDC42EP1,SEMA6A,SEMA3B,KIF13B,SFRP1,MAP4K4,LTK

GO:BP

Regulation of cellular component size

GO:0032535

0.049709667

1.30355914

383

132

12

17906

AQP1,SPP1,MAG,CNTN2,P2RX7,USH1C,SEMA4D,WIPF1,CDC42EP1,SEMA6A,SEMA3B,CFL2