Fig. 3
From: Altered hippocampal transcriptome dynamics following sleep deprivation
Distinct biological processes and cellular components are enriched for downregulated genes after acute sleep deprivation. a Pathway analysis using the PANTHER:BP classification to perform ORA, pathways enriched for downregulated genes were identified. Cell adhesion is the most significantly enriched network (Adjusted P-value = 2.91 × 10–3). The cell adhesion network has been expanded to show the genes that are involved and downregulated after sleep deprivation. b Using Network Analyst software and the PANTHER:CC classification to perform ORA we identified enriched cellular components for genes downregulated after sleep deprivation. The dendrite and postsynaptic membrane are the most significantly enriched cellular components (Adjusted P-value = 4.28 × 10–7). The size of each node represents the number of hits from the inputted gene list