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Fig. 1 | Molecular Brain

Fig. 1

From: Inhibition of autophagy by CRMP2-derived peptide ST2-104 (R9-CBD3) via a CaMKKβ/AMPK/mTOR pathway contributes to ischemic postconditioning-induced neuroprotection against cerebral ischemia-reperfusion injury

Fig. 1

ST2-104 decreases brain infarction and enhances neurological function in MCAO rats. a Representative coronal sections stained with triphenyl tetrazolium chloride (TTC) from rat brains in the sham, MCAO, MCAO + 3 mg/kg ST2-104 (L-ST2-104), and MCAO + 15 mg/kg ST2-104 (H-ST2-104) groups. TTC-stained red color indicates normal region, and white color is an infarct lesion (n = 6/group). b Bar graphs (with individual data points as indicated) of ischemic infarct volume measured following 24 h of the four groups as indicated (n = 6/group). c Quantification of the six-point scale neurological score of the four groups as indicated (n = 6/group). Scoring was performed by investigators blinded to the experimental condition. Data are presented as Mean ± SEM, analyzed by one-way analysis of variance (ANOVA). **P < 0.01 vs. Sham group; ##P < 0.01 vs. MCAO group

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