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Fig. 1 | Molecular Brain

Fig. 1

From: Similarities of developmental gene expression changes in the brain between human and experimental animals: rhesus monkey, mouse, Zebrafish, and Drosophila

Fig. 1

Similarities in temporal transcriptomics between brains of human and experimental animals: rhesus monkey, mouse, Zebrafish, and Drosophila. A–D The representative combination, which resulted in the lowest overlap P-value among all the data from developmental stages in each animal dataset (also see Additional file 2: Table S1), is indicated.  Comparison of gene expression patterns in the human hippocampus of 40–59-year-old adults compared with those of the hippocampal dentate gyrus of 6–12-year-old adult monkeys (A). The Venn diagram indicates that there were 546 common genes whose expression levels significantly changed with aging in both hippocampi of 40–59-year-old adults and hippocampal DG of 6–12-year-old adult monkeys, and the overlap P-value, as assessed by running Fisher analysis, was 2.1 × 10− 72. The right bar graphs indicate that, within the 546 common genes, the expression of 148 genes increased and 355 genes decreased in both humans and monkeys (i.e., positive correlation); expression of 15 genes increased and decreased in humans and monkeys, respectively; and the expression of 28 genes decreased and increased in humans and monkeys, respectively (i.e., negative correlation). The overlap P-values of these different types of correlations are also indicated above the corresponding bar graph. Likewise, gene expression patterns in the human hippocampus of 20–39-year-old adults compared with those of the hippocampal dentate gyrus of 29-day-old mice (B), gene expression patterns in the human hippocampus of 40–59-year-old adults compared with those of the brain of 1-2-year-old adult zebrafish (C), and gene expression patterns in the hippocampus of 6–11-year-old young humans compared with those of the 30-day old Drosophila brain (D), are indicated in the same manner with (A). DG dentate gyrus, E embryonic day, m.o. months old, yr year, d day

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