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Fig. 8 | Molecular Brain

Fig. 8

From: Anxiolytic effect of GABAergic neurons in the anterior cingulate cortex in a rat model of chronic inflammatory pain

Fig. 8

Chemogenetic inhibition of GABAergic neurons in the ACC enhanced the excitability of ACC PNs. The number of c-Fos cells per 0.1mm2 in the ipsilateral ACC (A) and contralateral ACC (B) of Control-mCherry-CNO and Control-hM4D(Gi)-CNO rats. n = 3–4. **P < 0.01, Control-hM4D(Gi) group vs Control-hM4D(Gi)-CNO group. C, D The firing rates in response to prolonged depolarizing current injections of increasing amplitudes in different groups. E, G The firing phenotypes changes of CNO application of PNs in ACC layer V. The input resistance (I, K), AP threshold (F, H) and membrane potentials (J, L) of PNs in ACC layer V were statistically analyzed in each group. Bar = 50 μm. n = 10 neurons from 5 rat/group. **P < 0.01, Control-hM4D(Gi) group vs Control-hM4D(Gi)-CNO group. All data represent the mean ± SEM

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