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Fig. 3 | Molecular Brain

Fig. 3

From: Histone modification of pain-related gene expression in spinal cord neurons under a persistent postsurgical pain-like state by electrocautery

Fig. 3

Long-lasting histone modification of Sprr1a and Anxa10 genes in the lumbar spinal cord after electrocautery treatment. A Schematic diagram of gene expression regulation by histone modification. B Workflow for experimental timeline. C Schematic diagram of ChIP-qPCR method. D Quantitative measurement of the levels of H3K27me3 (left) and H3K27ac (right) at the promoter region of the Sprr1a (black bar) and Anxa10 (gray bar) genes in the ipsilateral side of the lumber spinal cord at 11 days after electrocautery treatment. Each column represents the mean ± S.E.M. of 6 samples (H3K27me3, n = 5 animals per sample) or 3 samples (H3K27ac, n = 5 animals per sample) (unpaired t-test, *p < 0.05, ***p < 0.001 vs. sham group)

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Molecular Brain

ISSN: 1756-6606