Fig. 1

Behavior changes during fear conditioning and retrieval test. a Schematic diagram showing the experimental procedure for fear conditioning and retrieval test. b Percentage of freezing behavior across the conditioning and retrieval test sessions. Each dot represents the level of freezing when the tone stimulus was presented, except the first dot of each session, which shows the pre-tone baseline and the context test, respectively (Con, n = 16 mice; FC, n = 17 mice; two-way repeated-measures ANOVA, data are mean ± SEM). c Freezing in the context and tone stimulus during the retrieval test (Con-Context, n = 16 mice; FC-Context, n = 17 mice; Con-Tone 1, n = 16 mice; FC-Tone 1, n = 17 mice; Con-Tone 2, n = 16 mice; FC-Tone 2, n = 17 mice; one-way ANOVA, data are mean ± SEM; ****p < 0.0001 vs. Con, ^#p < 0.05, ^##p < 0.01 vs. Context). BL baseline, Con control, Context context test, FC fear conditioning