Comparative metabolic profiling of posterior parietal cortex, amygdala, and hippocampus in conditioned fear memory

Table 1 Pathway analysis of PPC metabolites altered in fear retrieval

Pathway name	p-value	FDR	Impact	Metabolites	Importance	FC	p-value
Pantothenate and CoA biosynthesis^a	0.0003	0.007	0.4107	PPanSH	0.2357	3.18	0.0006
Pantothenate and CoA biosynthesis^a	0.0003	0.007	0.4107	CoA	0.1750	1.31	0.0677
Purine metabolism	0.0005	0.007	0.1366	GMP	0.0609	1.16	0.0186
				Xanthine	0.0297	1.36	0.0050
				ADP	0.0210	0.83	0.0114
				dGDP	0.0084	0.76	0.0398
				ATP	0.0070	0.79	0.0470
				Deoxyguanosine	0.0051	1.22	0.0156
				Adenine	0.0046	1.33	0.0316
				ADPR	0.0000	1.79	< 0.0001
Tryptophan metabolism	0.0012	0.012	0.0139	Indoleacetaldehyde	0.0139	0.57	0.0036
Tryptophan metabolism	0.0012	0.012	0.0139	Acetyl-CoA	0.0000	1.16	0.0184
Pyruvate metabolism	0.0017	0.013	0.1540	Acetyl-CoA	0.1540	1.16	0.0184
				Acetyl adenylate	0.0000	0.55	0.0145
				Fumarate	0.0000	0.72	0.0595
Glutathione metabolism^a	0.0066	0.029	0.2560	Glutathione	0.2560	2.22	0.0444
Glutathione metabolism^a	0.0066	0.029	0.2560	Acetyl-CoA	0.0000	1.16	0.0184
Citrate cycle (TCA cycle)	0.0081	0.029	0.0992	Acetyl-CoA	0.0367	1.16	0.0184
				Succinate	0.0327	1.14	0.0977
				Fumarate	0.0298	0.72	0.0595

FC fold change, FDR false discovery rate, ADPR ADP-ribose, PPanSH 4′-Phosphopantetheine
^aPathway with high impact score (> 0.2)

ISSN: 1756-6606