Fig. 1

FMNT relieved anxiety-like behaviors in mice injected with CFA. a Schedule showing the experimental procedure. b Representative traces in OF test during a period of 15 min. Behavioral tests were performed on Day 14. c-e In OF test, administration with FMNT (25 mg/kg) for 8 days significantly increased the time (c) and distance (d) spent in the central area but had no effects on the total traveled distance (e). f Representative traces in EPM test during a period of 5 min. g-i FMNT treatment reversed the time spent in open arms (g) and closed arms (h). However, total arm entries had no difference among four groups (i). n = 7 per group. ^*p < 0.05, ^**p < 0.01 vs. control; ^#p < 0.05 vs. CFA